(1) Side effects of using hormones

This article will use the term steroid hormone, which does not mean that hormones are steroids. It's just the scientific term for any hormone-like substance produced in the body from cholesterol (it includes ketones, estrogen, and other substances like vitamin D). Hormones cannot be combined with illegal agonists for the following reasons: First, they need to be converted into a target hormone in order to have most of their anabolic effects. Because this requires a natural converting enzyme in the body, its conversion efficiency is limited, so the effect of taking it is also affected. The effect of steroids is dose-related, the greater the amount, the better the effect. Second, any such association is misleading because there are no legal substances that can compare to steroids and their effects. I'm outraged that some companies are trying to market their hormones by giving them names that sound like steroids. Products like Maxteron (5a-androstane-3b, 17b-diol; 5-AA), Decavar (main ingredients 4-AD, Tribulus, ZMA, etc.) and many others are giving our youth a bad head because they make They are familiar with steroids and use it because of it. This kind of reckless behavior, I think, will be the reason why hormones will eventually be banned by the FDA - a very dangerous move that will happen in the near future. Please read the paragraph below to understand the side effects of this substance. If you're looking for ways to reduce this side effect, skip directly to the Frequently Asked Questions (FAQ) section.

　1. Inhibition of natural ketones through negative feedback

Taking exogenous steroid hormones will inhibit the natural production of ketone hormones from the beginning through a mechanism called negative feedback. Negative feedback is a loop mechanism: first, the hypothalamus secretes gonadotropin-releasing hormone (GnRH), which stimulates the anterior pituitary gland to produce and release luteinizing hormone (LH; gonadotropin). In the pill, luteinizing hormone stimulates the pill. Interstitial cells synthesize dehydroepipione (DHEA) from cholesterol. DHEA is converted into androstenedione and ultimately into ?one. When the secretion of ketone meets the needs of the body, ketone will send a feedback signal to the hypothalamus, and the secretion will stop. Direct ingestion of these substances outside the body will produce the same feedback signal and stop ketone production. Why is this bad? Because the synthesis of DHEA in the gonads (?pills) stops and they are in a state of disuse, which will cause the ??pills to shrink, which will eventually lead to infertility, loss of sexual function and even impotence. This question gave rise to the term cycle: taking a hormone for a period of time and then stopping it for an equal or longer period of time to give the body's natural synthetic processes a chance to recover. Mild atrophy may occur but will disappear after a period of discontinuation. Therefore the conclusionThat is:

(1) This substance should always be used periodically, as long-term or continued use may cause more lasting damage. According to my experience, 10 weeks should be the maximum time of use of a hormone combination, and even then there is still a possibility of overdose. I usually recommend no more than 8 weeks.

(2) The time to stop using hormones should be long enough, at least not less than, and preferably longer than the time of use. If this rule is not followed, the pill may not have enough time to recover. The cumulative effect of two cycle periods that are too close can also cause this problem.

　2. Estrogen-related issues

Estrogen is a general term for a group of hormones related to female sexual characteristics, and is obviously more active in our female bodies. Estradiol and the metabolite estrone are the strongest and most relevant estrogens. There are many estrogens that are inactive in the body and do not require any attention. In the body, as the hormone is converted, a portion (the exact amount varies depending on the hormone used) is converted into estrogen. Even if this is not the case, its target hormones, especially ketones, can undergo an aromatization process, converting ketones to estradiol, which occurs at the carbon base in position 3 (most anabolic steroid hormones With 17 carbon atoms), forming an A ring.

So what will be the result? Well, the first is the feminizing effect that occurs in men. Estrogen has a strong water-sodium retaining effect, which means that a lot of water will be stored in the body, making you bulky, but not muscular. When the estrogen:ketone ratio returns to normal levels, most of the water will disappear again. Water and sodium retention itself has a mild anabolic effect and is not harmful as long as it does not affect ketone content. It also increases the chance of body fat storage (women generally have a higher body fat % (BF%) than men). What attracts more attention is gynecomastia, which refers to the excessive development of male breast tissue due to the influence of estrogen. Alcohol and excess body fat can also cause this condition, so keep in mind the dangers of these conditions affecting your breast development. So far I am not aware of anyone experiencing severe breast development from taking hormone pills. Usually that happens when substances that are easily converted, such as amizole or 5-AD (5-diol), are taken at a dose that has no additional effect. What is more common is that the nipples become itchy and bloated. These are common symptoms and will go away on their own. Itching is not a symptom, but if it becomes bloated, it's worth considering. If you're on an 8-week combination cycle and you feel some swelling at week 5 or 6, there's not necessarily much danger in continuing to take it. Most of the effects are reversible and will disappear 3 weeks after stopping taking it. If you experience obvious bloating in the first week of taking it, don’t hesitate and stop immediately. If you are obviously sensitive to hormones, it would be unwise to continue using them. There is a much greater risk that this phenomenon will become permanent, and if gynecomastia occurs, the only treatment is surgical removal. But, as I said, I stillNeed to see the first confirmed case.

　3. Androgen-related issues

Androgens refer to any substance that can cause the body to produce male sexual characteristics (also called a masculine effect, if you like). You may think that this is a positive thing, and usually it is, but there are exceptions. . Most problems related to androgens are related to dihydrosteroid (DHT). FSH (follicle-stimulating hormone, another sex hormone that affects pituitary gland secretion after GnRH) regulates Sertoli cells to convert ketones into DHT. DHT is associated with sperm maturation and most male signs. Increased body hair, thicker voice, and increased sexual desire are common phenomena that no one should worry about. The real issue that people are concerned about is that like all fat-soluble substances (ketones are made of cholesterol), they are stored under the skin, and DHT seems to have a special affinity for the scalp, which will affect the development of the scalp and lead to hair loss.